Nasal Spray Restores Memory in Ageing Brains

A new nasal spray therapy has reversed key signs of brain ageing and improved memory in laboratory studies, raising hopes for future treatments that support healthier cognitive ageing in the United States.

“Our approach redefines what it means to grow old,” said Dr Ashok K. Shetty, University Distinguished Professor at Texas A&M University College of Medicine, USA. “We’re aiming for successful brain ageing: keeping people engaged, alert and connected.”

The therapy uses microscopic extracellular vesicles that carry microRNAs and are delivered directly to the brain via a nasal spray. In the study, just two doses reduced chronic inflammation, restored mitochondrial function and improved memory performance within weeks, with benefits lasting for months. Researchers found the treatment worked similarly in both males and females and believe it could eventually help address age-related cognitive decline and neurodegenerative conditions. The team has filed a US patent and plans further research to explore its potential in human therapies.